Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support
growth, a metabolic alteration commonly referred to as the “Warburg effect.” Here, we show …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The serine/threonine kinase Akt inhibits mitochondrial cytochrome c release and apoptosis
induced by a variety of proapoptotic stimuli. The antiapoptotic activity of Akt is coupled, at …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a
neurodegenerative disease characterized by loss of motor neurons. With conformation …

Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …

Akt activation supports survival of cardiomyocytes against ischemia/reperfusion, which
induces cell death through opening of the mitochondrial permeability transition pore (PT …