Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Robustness is a ubiquitously observed property of biological systems. It is considered to be
a fundamental feature of complex evolvable systems. It is attained by several underlying …

Protein and messenger RNA (mRNA) copy numbers vary from cell to cell in isogenic
bacterial populations. However, these molecules often exist in low copy numbers and are …

Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …

Bacterial gene expression depends not only on specific regulatory mechanisms, but also on
bacterial growth, because important global parameters such as the abundance of RNA …

Noise, or random fluctuations, in gene expression may produce variability in cellular
behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the …

It has become customary to conceptualize the living cell as an intricate piece of machinery,
different to a man-made machine only in terms of its superior complexity. This familiar …

This survey addresses stability analysis for stochastic hybrid systems (SHS), which are
dynamical systems that combine continuous change and instantaneous change and that …