The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Most genetic variations associated with human complex traits are located in non-coding
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …

Similar to other complex organisms, plants consist of diverse and specialized cell types. The
gain of unique biological functions of these different cell types is the consequence of the …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …

Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal
gene expression patterns in distinct cell types. Non-coding genetic variants can influence …

Aging, a universal process that affects all cells in an organism, is a major risk factor for a
group of neuropathies called glaucoma, where elevated intraocular pressure is one of the …

Multifaceted and divergent manifestations across tissues and cell types have curtailed
advances in deciphering the cellular events that accompany advanced age and contribute to …

Self-organization is a process that ensures histogenesis of the eye retina. This highly
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …

Regulation of chromatin plays fundamental roles in the development of the brain.
Haploinsufficiency of the chromatin remodeling enzyme CHD7 causes CHARGE syndrome …

To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids
from two states (expandable and more differentiated) were subjected to single-cell RNA-seq …