Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
W Zhang, D Trachootham, J Liu, G Chen… - Nature cell …, 2012 - nature.com
Tissue stromal cells interact with leukaemia cells and profoundly affect their viability and
drug sensitivity. Here we show a biochemical mechanism by which bone marrow stromal …
drug sensitivity. Here we show a biochemical mechanism by which bone marrow stromal …
[HTML][HTML] Chronic lymphocytic leukemia: prognostic factors and impact on treatment
TL Parker, MP Strout - Discovery medicine, 2011 - discoverymedicine.com
Chronic lymphocytic leukemia (CLL) is a clonal malignancy of mature B cells that displays
immense clinical heterogeneity as reflected by the observation that many patients have an …
immense clinical heterogeneity as reflected by the observation that many patients have an …
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
D Trachootham, H Zhang, W Zhang… - Blood, The Journal …, 2008 - ashpublications.org
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, and resistance to
fludarabine-based therapies is a major challenge in CLL treatment. Because CLL cells are …
fludarabine-based therapies is a major challenge in CLL treatment. Because CLL cells are …
[HTML][HTML] HIF-1α is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia
V Griggio, C Vitale, M Todaro, C Riganti… - …, 2020 - ncbi.nlm.nih.gov
In chronic lymphocytic leukemia (CLL), the hypoxia-inducible factor 1 (HIF-1) regulates the
response of tumor cells to hypoxia and their protective interactions with the leukemic …
response of tumor cells to hypoxia and their protective interactions with the leukemic …
[HTML][HTML] MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
M Ferracin, B Zagatti, L Rizzotto, F Cavazzini… - Molecular cancer, 2010 - Springer
Background Fludarabine, is one of the most active single agents in the treatment of chronic
lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become …
lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become …
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
E Willmore, SL Elliott, T Mainou-Fowler… - Clinical cancer …, 2008 - AACR
Abstract Purpose: del (17p), del (11q), and associated p53 dysfunction predict for short
survival and chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA …
survival and chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA …
Signalling to drug resistance in CLL
E Hertlein, JC Byrd - Best practice & research Clinical haematology, 2010 - Elsevier
The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling
pathway is constitutively active in a variety of cancers, including chronic lymphocytic …
pathway is constitutively active in a variety of cancers, including chronic lymphocytic …
Enhanced singlet oxygen production by photodynamic therapy and a novel method for its intracellular measurement
SLP Luengas, GH Marin, K Aviles… - Cancer Biotherapy …, 2014 - liebertpub.com
The generation of singlet oxygen (SO) in the presence of specific photosensitizers (PSs) or
semiconductor quantum dots (QDs) and its application in photodynamic therapy (PDT) is of …
semiconductor quantum dots (QDs) and its application in photodynamic therapy (PDT) is of …
[HTML][HTML] Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts
Subclonal heterogeneity and clonal selection influences disease progression in chronic
lymphocytic leukemia (CLL). It is therefore important that therapeutic decisions are made …
lymphocytic leukemia (CLL). It is therefore important that therapeutic decisions are made …
[HTML][HTML] Prognostication of DNA damage response protein expression patterns in chronic lymphocytic leukemia
Proteomic DNA Damage Repair (DDR) expression patterns in Chronic Lymphocytic
Leukemia were characterized by quantifying and clustering 24 total and phosphorylated …
Leukemia were characterized by quantifying and clustering 24 total and phosphorylated …