Recent advances in biocompatible ionic liquids in drug formulation and delivery
The development of effective drug formulations and delivery systems for newly developed or
marketed drug molecules remains a significant challenge. These drugs can exhibit …
marketed drug molecules remains a significant challenge. These drugs can exhibit …
An update on synthesis, properties, applications and toxicity of the ILs
APS Raman, MB Singh, P Jain, P Chaudhary… - Journal of Molecular …, 2022 - Elsevier
Ionic liquids (ILs) have been in utility since the beginning of the 1980s due to their vast
range of features, uses, and environmentally acceptable nature. They have been presented …
range of features, uses, and environmentally acceptable nature. They have been presented …
Investigation of patient-centric 3D-printed orodispersible films containing amorphous aripiprazole
The objective of this study was to design and evaluate an orodispersible film (ODF)
composed of aripiprazole (ARP), prepared using a conventional solvent casting technique …
composed of aripiprazole (ARP), prepared using a conventional solvent casting technique …
Utilization of Lipophilic Salt and Phospholipid Complex in Lipid-Based Formulations to Modulate Drug Loading and Oral Bioavailability of Pazopanib
Pazopanib hydrochloride (PAZ) displays strong intermolecular interaction in its crystal lattice
structure, limiting its solubility and dissolution. The development of lipid-based formulations …
structure, limiting its solubility and dissolution. The development of lipid-based formulations …
Study and computational modeling of fatty acid effects on drug solubility in lipid-based systems
N Wyttenbach, A Niederquell, P Ectors… - Journal of Pharmaceutical …, 2022 - Elsevier
Lipid-based systems have many advantages in formulation of poorly water-soluble drugs but
issues of a limited solvent capacity are often encountered in development. One of the …
issues of a limited solvent capacity are often encountered in development. One of the …
Rationalizing Counterion Selection for the Development of Lipophilic Salts: A Case Study with Venetoclax
The use of lipid-based formulations (LBFs) can be hindered by low dose loading due to
solubility limitations of candidate drugs in lipid vehicles. Formation of lipophilic salts through …
solubility limitations of candidate drugs in lipid vehicles. Formation of lipophilic salts through …
Enabling superior drug loading in lipid-based formulations with lipophilic salts for a brick dust molecule: Exploration of lipophilic counterions and in vitro-in vivo …
Lipid-based formulations (LbFs) are an extensively used approach for oral delivery of poorly
soluble drug compounds in the form of lipid suspension and lipid solution. However, the …
soluble drug compounds in the form of lipid suspension and lipid solution. However, the …
Biocompatible cationic lipoamino acids as counterions for oral administration of API-ionic liquids
Purpose The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
On the use of linear model-based optimization to obtain optimum solubility permeability balance (OSPB) in cinnarizine-hydrotropic blends
The objectives of this work are (1) To scrutinize the various hydrotropes for acting as
cinnarizine solubility augmenting excipient,(2) To show the existence of solubility …
cinnarizine solubility augmenting excipient,(2) To show the existence of solubility …
Solid Drug Nanoparticles
C Unsworth, AC Savage, SP Rannard - Fundamentals of Pharmaceutical …, 2024 - Springer
Solid drug nanoparticles (SDNs) are formulations in which the drug presents as a sub-
micron particle stabilised by surfactants, polymers or sugars. These formulations are …
micron particle stabilised by surfactants, polymers or sugars. These formulations are …