Pancreatic ductal adenocarcinoma co-opts multiple cellular and extracellular mechanisms to
create a complex cancer organ with an unusual proclivity for metastasis and resistance to …

Background Pancreatic ductal adenocarcinoma (PDA) is characterised by a robust
desmoplasia, including the notable accumulation of immunosuppressive cells that shield …

Adoptive T‐cell therapy involves the isolation, expansion, and reinfusion of T lymphocytes
with a defined specificity and function as a means to eradicate cancer. Our research has …

Melanoma researchers utilize cell lines to model many tumour phenomena. It is thus
important to understand similarities and differences between cell lines and the tumours that …

Personalized cancer immunotherapy based on infusion of T cells holds the promise to
specifically target a patient's individual tumor. Accumulating evidence indicates that the T …

Human PAICS is a bifunctional enzyme that is involved in the de novo purine biosynthesis,
catalyzing the conversion of aminoimidazole ribonucleotide (AIR) into N …

Melanoma is the least common but most fatal form of skin cancer. Previous studies have
indicated that an aqueous extract of Hibiscus sabdariffa leaves possess hypoglycemic …

Background: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole
succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine …

Studies of alternative RNA splicing (ARS) have the potential to provide an abundance of
novel targets for development of new biomarkers and therapeutics in oncology, which will be …

Background Non-synonymous mutations altering tumor suppressor genes and oncogenes
are widely studied. However, synonymous mutations, which do not alter the protein …