The neocortex is disproportionately expanded in human compared with mouse,, both in its
total volume relative to subcortical structures and in the proportion occupied by …

The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective
autophagy pathway, known as ER-phagy. ER-phagy receptors have a central role in this …

Actin filament formation plays a pivotal role in the development, regeneration and
modulation of the morphologies and physiological functions of subcellular compartments …

Recent large-scale genomic association studies found evidence for a genetic link between
increased risk of type 2 diabetes and decreased risk for adiposity-related traits, reminiscent …

Cells of multicellular organisms need to adopt specific morphologies. However, the
molecular mechanisms bringing about membrane topology changes are far from understood …

The neocortex is disproportionately expanded in human compared to mouse, both in its total
volume relative to subcortical structures and in the proportion occupied by supragranular …

Membrane-shaping proteins are driving forces behind establishment of proper cell
morphology and function. Yet, their reported structural and in vitro properties are noticeably …

The complex architecture of neuronal networks in the brain requires tight control of the actin
cytoskeleton. The actin nucleator Cobl is critical for neuronal morphogenesis. Here we …

Cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex,
heterogeneous etiology. It is well established that common and rare sequence variants …

Ischemic stroke is a major cause of death and long-term disability. We demonstrate that
middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic …