Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under
stress. It has alternately been argued that NAD in mammalian mitochondria arises from …

The functional cofactors derived from vitamin B3 are nicotinamide adenine dinucleotide
(NAD+), its phosphorylated form, nicotinamide adenine dinucleotide phosphate (NADP+) …

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence
indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is …

Proteins controlling mitochondrial fission have been recognized as essential regulators of
mitochondrial functions, mitochondrial quality control and cell apoptosis. In the present …

It is a textbook definition that in the absence of oxygen or inhibition of the mitochondrial
respiratory chain by pharmacologic or genetic means, hyper-reduction of the matrix pyridine …

NBS1, a protein linked to the autosomal recessive disorder Nijmegen breakage syndrome,
plays an essential role in the DNA damage response and DNA repair. Despite its …

The mammalian NUDT13 protein possesses a sequence motif characteristic of the NADH
pyrophosphohydrolase subfamily of Nudix hydrolases. Due to the persistent insolubility of …