RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …

Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune
diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 …

The development of cancer vaccines has been intensively pursued over the past 50 years
with modest success. However, recent advancements in the fields of genetics, molecular …

Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Genetically engineered T cells have sparked interest in advanced cancer treatment,
reaching a milestone in 2017 with two FDA-approvals for CD19-directed chimeric antigen …

Abnormal gene expression level or expression of genes containing deleterious mutations
are two of the main determinants which lead to genetic disease. To obtain a therapeutic …

Efficient intracellular delivery of target macromolecules remains a major obstacle in cell
engineering and other biomedical applications. We discovered a unique cell biophysical …

Biomaterials play a critical role in technologies intended to deliver therapeutic agents in
clinical settings. Recent explosion of our understanding of how cells utilize nucleic acids has …