The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target
was a major breakthrough for the treatment of highly aggressive HER2-positive breast …

Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over
the past decade, particularly in developmental biology, cancer, immunology, and …

Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

Characterization of the tumor microenvironment through immunoprofiling has become an
essential resource for the understanding of the complex immune cell interactions and the …

Solid tumours comprise many different cell types organized in spatially structured
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …

Simple Summary In breast cancer, there is a high degree of variability in tumors and the
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …

Purpose: Neoadjuvant chemotherapy is increasingly administered to patients with
resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC), yet its …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the
composition of the tumor microenvironment. Gene expression identified a high myeloid …

Simple Summary The spread of breast cancer to distant parts of the body (metastasis) is the
major cause of death in breast cancer patients. Research has shown that apart from the …