Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy
T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
A Maharati, M Moghbeli - Cell Communication and Signaling, 2023 - Springer
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …
considered as a global health challenge. Despite many progresses in therapeutic methods …
[HTML][HTML] Colorectal cancer carcinogenesis: a review of mechanisms
Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …
common in men globally. CRC arises from one or a combination of chromosomal instability …
PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: a review of preclinical and clinical evidence
A Narayanankutty - Current drug targets, 2019 - ingentaconnect.com
Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …
and involved in the regulation of cellular proliferation, differentiation and survival …
Portrait of the PI3K/AKT pathway in colorectal cancer
SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic colon epithelium to promote cancer cell proliferation and inhibit apoptosis
KS Bishnupuri, DM Alvarado, AN Khouri, M Shabsovich… - Cancer research, 2019 - AACR
The tryptophan-metabolizing enzyme indoleamine 2, 3 dioxygenase 1 (IDO1) is frequently
overexpressed in epithelial-derived malignancies, where it plays a recognized role in …
overexpressed in epithelial-derived malignancies, where it plays a recognized role in …
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
FVN Din, A Valanciute, VP Houde, D Zibrova… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Aspirin reduces the incidence of and mortality from colorectal
cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the …
cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the …
Mechanism of apoptosis induced by curcumin in colorectal cancer
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response
The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase
(PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but …
(PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but …