Drug delivery strategies for antibiofilm therapy

V Choi, JL Rohn, P Stoodley, D Carugo… - Nature Reviews …, 2023 - nature.com
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …

Biofilm Formation in Medically Important Candida Species

Z Malinovská, E Čonková, P Váczi - Journal of Fungi, 2023 - mdpi.com
Worldwide, the number of infections caused by biofilm-forming fungal pathogens is very
high. In human medicine, there is an increasing proportion of immunocompromised patients …

Emerging and future strategies in the management of recalcitrant Candida auris

N Bandara, L Samaranayake - Medical Mycology, 2022 - academic.oup.com
Candida auris is an emerging, multi drug resistant fungal pathogen that has caused
infectious outbreaks in over 45 countries since its first isolation over a decade ago, leading …

Antifungal Resistance in Candida auris: Molecular Determinants

MG Frías-De-León, R Hernández-Castro, T Vite-Garín… - Antibiotics, 2020 - mdpi.com
Since Candida auris integrates strains resistant to multiple antifungals, research has been
conducted focused on knowing which molecular mechanisms are involved. This review aims …

Augmenting azoles with drug synergy to expand the antifungal toolbox

A Kane, DA Carter - Pharmaceuticals, 2022 - mdpi.com
Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris

M Billamboz, Z Fatima, S Hameed, S Jawhara - Microorganisms, 2021 - mdpi.com
Invasive fungal infections represent an expanding threat to public health. During the past
decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida …

Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms

R Kovács, L Majoros - Journal of Fungi, 2020 - mdpi.com
The number of effective therapeutic strategies against biofilms is limited; development of
novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum …

Drug repurposing against Candida auris: A systematic review

A Izadi, S Aghaei Gharehbolagh, F Sadeghi… - Mycoses, 2022 - Wiley Online Library
Candida auris is a drug‐resistant pathogen with several reported outbreaks. The treatment
of C. auris infections is difficult due to a limited number of available antifungal drugs. Thus …

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Y Li, C Chen, L Cong, S Mao, M Shan, Z Han, J Mao… - Virulence, 2023 - Taylor & Francis
Candidiasis caused by Candida albicans infection has long been a serious human health
problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are …

Galleria mellonella for systemic assessment of anti-Candida auris using amphotericin B loaded in nanoemulsion

GD Marena, MADS Ramos, LC Lima, M Chorilli… - Science of The Total …, 2022 - Elsevier
Galleria mellonella is a model that uses adult larvae to assess the prophylactic, therapeutic,
and acute toxic potential of substances. Given their benefits, G. mellonella models are being …