Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

Drug‐induced alterations in gene expression throughout the reward circuitry of the brain are
likely components of the persistence of the drug‐addicted state. Recent studies examining …

Substance abuse increases an individual's vulnerability to stress-related illnesses, which is
presumably mediated by drug-induced neural adaptations that alter subsequent responses …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region,
promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) …

Drug addiction is responsible for millions of deaths per year around the world. Still, its
management as a chronic disease is shadowed by misconceptions from the general public …

The regulation of gene expression in the brain reward regions is known to contribute to the
pathogenesis and persistence of drug addiction. Increasing evidence suggests that the …

The gut microbiome modulates neurochemical function and behavior and has been
implicated in numerous central nervous system (CNS) diseases, including developmental …

Cocaine exposure triggers molecular events that lead to long-lasting changes in brain
structure and function. These changes can lead to the development of persistent and robust …

The detrimental effects of drug abuse are apparently not limited to individuals but may also
impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic …