The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

V-set and immunoglobulin domain containing 4 (VSIG4), a type I transmembrane receptor
exclusively expressed in a subset of tissue-resident macrophages, plays a pivotal role in …

Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general
surgery, is characterized by acute and rapid onset as well as high mortality, which often …

Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver
homeostasis. How the KC pool varies upon injury remains unclear. Using chimeric mice with …

Resident macrophages play a unique role in the maintenance of tissue function. As
phagocytes, they are an essential first line defenders against pathogens and much of the …

The liver is a vital metabolic organ that also performs important immune-regulatory functions.
In the context of infections, the liver represents a target site for various pathogens, while also …

Abstract Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the
tumour microenvironment. Their roles in the cancer immunity are complicated, both pro …

The mechanism by which mammalian liver cell responses are coordinated during tissue
homeostasis and perturbation is poorly understood, representing a major obstacle in our …