Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

Abstract N6‐methyladenosine (m6A) is an abundant nucleotide modification in mRNA,
known to regulate mRNA stability, splicing, and translation, but it is unclear whether it is also …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Maintenance of a healthy proteome is essential for cellular homeostasis and loss of
proteostasis is associated with tissue dysfunction and neurodegenerative disease. The …