Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair
JR Siebert, A Conta Steencken… - BioMed research …, 2014 - Wiley Online Library
Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central
nervous system, serving as guidance cues during development and modulating synaptic …
nervous system, serving as guidance cues during development and modulating synaptic …
Polyethylene glycol in spinal cord injury repair: a critical review
Polyethylene glycol (PEG) is a synthetic biocompatible polymer with many useful properties
for developing therapeutics to treat spinal cord injury. Direct application of PEG as a fusogen …
for developing therapeutics to treat spinal cord injury. Direct application of PEG as a fusogen …
Local delivery of chondroitinase ABC with or without stromal cell-derived factor 1α promotes functional repair in the injured rat spinal cord
MM Pakulska, CH Tator, MS Shoichet - Biomaterials, 2017 - Elsevier
Traumatic spinal cord injury (SCI) is a devastating event for which functional recovery
remains elusive. Due to the complex nature of SCI pathology, a combination treatment …
remains elusive. Due to the complex nature of SCI pathology, a combination treatment …
Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal …
The lack of tissue regeneration after traumatic spinal cord injury in animal models is largely
attributed to the local inhibitory microenvironment. To overcome this inhibitory environment …
attributed to the local inhibitory microenvironment. To overcome this inhibitory environment …
Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains
Central nervous system (CNS) injuries, such as stroke and spinal cord injuries, result in the
formation of a proteoglycan-rich glial scar, which acts as a barrier to axonal regrowth and …
formation of a proteoglycan-rich glial scar, which acts as a barrier to axonal regrowth and …
Improvement of chondroitinases ABCI stability in natural deep eutectic solvents
Deep eutectic solvents (DESs) are of great importance in enzymatic reactions. They facilitate
the effective contact between reactants and enzymes, thereby can affect the activity …
the effective contact between reactants and enzymes, thereby can affect the activity …
Biomaterial approaches to enhancing neurorestoration after spinal cord injury: strategies for overcoming inherent biological obstacles
JR Siebert, AM Eade… - BioMed research …, 2015 - Wiley Online Library
While advances in technology and medicine have improved both longevity and quality of life
in patients living with a spinal cord injury, restoration of full motor function is not often …
in patients living with a spinal cord injury, restoration of full motor function is not often …
Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability
Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC
(ChABC) has shown promise in central nervous system (CNS) regeneration, yet its …
(ChABC) has shown promise in central nervous system (CNS) regeneration, yet its …
Efficient electroenzymatic cascade catalysis for ortho-selective chlorination of phenol
The integration of enzymatic catalysis and electrocatalysis is promising for developing new
green techniques for chemical production; however, how to coordinate the two processes for …
green techniques for chemical production; however, how to coordinate the two processes for …
Synthesis and evaluation of nanosystem containing chondroitinase ABCI based on hydroxyapatite
The bacterial enzyme chondroitinase ABCI (chABCI), which has been isolated from Proteus
Vulgaris, is crucial in the treatment of spinal cord injuries. However, due to its short lifespan …
Vulgaris, is crucial in the treatment of spinal cord injuries. However, due to its short lifespan …