Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …

The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …

The immune system is a complex network of cells with critical functions in health and
disease. However, a comprehensive census of the cells comprising the immune system is …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Sexual dimorphisms account for differences in clinical manifestations or incidence of
infectious or autoimmune diseases and malignancy between females and males. Females …

Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …