Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Covering: up to 2021 Terpenoids are physiologically active substances that are of great
importance to humans. Their physicochemical properties are modified by glycosylation, in …

The study of drug–protein interactions can reveal the corresponding binding mechanisms,
providing valuable information for the early phase drug development and development of …

With the growing acceptance of the contribution of protein conformational ensembles to
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …

Biotherapeutics and their biosimilar versions have been flourishing in the biopharmaceutical
market for several years. Structural and functional characterization is needed to achieve …

This review explores the diverse applications of deuterium in medicinal chemistry,
particularly as an analytical tool in mass spectrometry. Deuterium applications extend …

Heterogeneity of therapeutic Monoclonal antibody (mAb) drugs are due to protein variants
generated during the manufacturing process. These protein variants can be critical quality …

Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins
designed to bind pharmacological targets are covalently linked or expressed as fusion …

An important element of antibody-guided vaccine design is the use of neutralizing or
opsonic monoclonal antibodies to define protective epitopes in their native three …

A central challenge in structural biology is represented by dynamic and heterogeneous
systems, as typically represented by proteins in solution, with the extreme case of …