Neuromuscular basis of Drosophila larval rolling escape behavior

PC Cooney, Y Huang, W Li… - Proceedings of the …, 2023 - National Acad Sciences
When threatened by dangerous or harmful stimuli, animals engage in diverse forms of rapid
escape behaviors. In Drosophila larvae, one type of escape response involves C-shaped …

[HTML][HTML] Excess glutamate release triggers subunit-specific homeostatic receptor scaling

Y Han, P Goel, J Chen, S Perry, N Tran, S Nishimura… - Cell reports, 2023 - cell.com
Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and
homeostatic synaptic plasticity and are remodeled by development, experience, and …

[HTML][HTML] Molecular and organizational diversity intersect to generate functional synaptic heterogeneity within and between excitatory neuronal subtypes

AT Medeiros, SJ Gratz, A Delgado, JT Ritt… - eLife, 2023 - elifesciences.org
Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and
responsive communication in neural circuits. In this study, we investigated the contributions …

Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

AT Medeiros, SJ Gratz, A Delgado, JT Ritt… - Elife, 2024 - elifesciences.org
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …

Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging

A Mrestani, S Dannhäuser, M Pauli… - Life Science …, 2023 - life-science-alliance.org
Chemical synaptic transmission involves neurotransmitter release from presynaptic active
zones (AZs). The AZ protein Rab-3-interacting molecule (RIM) is important for normal Ca2+ …

Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity.

AT Medeiros, SJ Gratz, A Delgado, JT Ritt… - Elife, 2024 - search.ebscohost.com
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and
adaptable communication in neural circuits. To understand circuit function, it is thus critical to …

To Ib or not to b: Transcriptional regulation of tonic type Ib vs. phasic type Is motor neurons

AT Medeiros, K O'Connor-Giles - Neuron, 2023 - cell.com
Neuronal diversity is a hallmark of the nervous system that has captivated scientists for over
a century. In this issue of Neuron, Suresh Jetti and colleagues report the identification of …

Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals

KA Justs, S Sempertegui, DV Riboul… - The Journal of …, 2023 - Wiley Online Library
Motor neurons are the longest neurons in the body, with axon terminals separated from the
soma by as much as a meter. These terminals are largely autonomous with regard to their …

A stochastic RNA editing process targets a limited number of sites in individual Drosophila glutamatergic motoneurons

AB Crane, SK Jetti, JT Littleton - bioRxiv, 2024 - biorxiv.org
RNA editing is a post-transcriptional source of protein diversity and occurs across the animal
kingdom. Given the complete profile of mRNA targets and their editing rate in individual cells …

[HTML][HTML] Distinct input-specific mechanisms enable presynaptic homeostatic plasticity

C Chien, K He, S Perry, E Tchitchkan, Y Han, X Li… - …, 2024 - pmc.ncbi.nlm.nih.gov
Synapses are endowed with the flexibility to change through experience, but must be
sufficiently stable to last a lifetime. This tension is illustrated at the Drosophila …