Tenofovir, another inexpensive, well-known and widely available old drug repurposed for SARS-COV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is spreading
worldwide with different clinical manifestations. Age and comorbidities may explain severity …
worldwide with different clinical manifestations. Age and comorbidities may explain severity …
Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies
M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
Repositioning of acefylline as anti-cancer drug: Synthesis, anticancer and computational studies of azomethines derived from acefylline tethered 4-amino-3-mercapto …
Novel azomethines derived from acefylline tethered triazole hybrids (7a-k) have been
synthesized and evaluated against human liver cancer cell line (Hep G2) using MTT assay …
synthesized and evaluated against human liver cancer cell line (Hep G2) using MTT assay …
[HTML][HTML] Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp)
SM Patil, KR Maruthi, SN Bajpe, VM Vyshali… - …, 2021 - ncbi.nlm.nih.gov
Abstract Treatment of SARS-CoV-2 targeting its RNA dependent RNA polymerase (RdRp) is
of current interest. Remdesivir has been approved for the treatment of COVID-19 around the …
of current interest. Remdesivir has been approved for the treatment of COVID-19 around the …
The impact of D614G mutation of SARS-COV-2 on the efficacy of anti-viral drugs: A comparative molecular docking and molecular dynamics study
D614G is one of the most reported mutations in the spike protein of SARS-COV-2 that has
altered some crucial characteristics of coronaviruses, such as rate of infection and binding …
altered some crucial characteristics of coronaviruses, such as rate of infection and binding …
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and …
Abstract β-Amino alcohols (2–4) used in this study were re-synthesized in accordance with
our previous study. All compounds were characterized by the combination of NMR, UV–Vis …
our previous study. All compounds were characterized by the combination of NMR, UV–Vis …
Synthesis, structural confirmation, antibacterial properties and bio-informatics computational analyses of new pyrrole based on 8-hydroxyquinoline
Y Lakhrissi, M Rbaa, B Tuzun, A Hichar… - Journal of Molecular …, 2022 - Elsevier
This study aims to synthesize new pyrrolic compounds derivatives of 8-hydroxyquinoline,
explore the structure-activity relationship and the effect of the substituents carried by the …
explore the structure-activity relationship and the effect of the substituents carried by the …
In silico SELEX screening and statistical analysis of newly designed 5mer peptide-aptamers as Bcl-xl inhibitors using the Taguchi method
Drug development for cancer treatment is a complex process that requires special efforts.
Targeting crucial proteins is the most essential purpose of drug design in cancers. Bcl-xl is …
Targeting crucial proteins is the most essential purpose of drug design in cancers. Bcl-xl is …
A biochemistry‐oriented drug design: synthesis, anticancer activity, enzymes inhibition, molecular docking studies of novel 1, 2, 4-triazole derivatives
K Yuriy, G Kusdemir, P Volodymyr… - Journal of …, 2024 - Taylor & Francis
In this study, we researched the reactions of 5-(5-bromofuran-2-yl)-4-methyl-1, 2, 4-triazole-3-
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …
Modeling and affinity maturation of an anti-CD20 nanobody: a comprehensive in-silico investigation
B-cell Non-Hodgkin lymphomas are the malignancies of lymphocytes. CD20 is a membrane
protein, which is highly expressed on the cell surface of the B-cells in NHL. Treatments using …
protein, which is highly expressed on the cell surface of the B-cells in NHL. Treatments using …