Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

In recent years, there has been an ever‐increasing need for rapid reactions that meet the
three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions …

Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of
heterocyclic rings, with applications in different fields. In this review we focus on the …

Introduction: The copper (I)-catalyzed 1, 3-dipolar cycloaddition of alkynes and azides to
form 1, 2, 3-triazoles is the most popular reaction in click chemistry. This reaction is also near …

This critical review concerns the impact of copper-mediated alkyne–azide cycloadditions on
peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into …

Highlights•Advances in the combination of the CuAAC reaction with direct screening.•Before
library assembly, the bioisosteric potential of 1, 2, 3-triazole should be confirmed.•The …

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates,
each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via …

Click chemistry and medicinal chemistry: a case of "cyclo-addiction" - CSHL Scientific
Digital Repository CSHL Scientific Digital Repository Home User Guide Stats About Year …