Diagnosing viral encephalitis and emerging concepts

HYF Yong, DM Pastula, RK Kapadia - Current Opinion in …, 2023 - journals.lww.com
Although etiological diagnosis remains challenging in viral encephalitis, recent advances
may soon provide the clinician with additional tools. Environmental changes, host factors …

Immune-triggered forms of plasticity across brain regions

M Hikosaka, T Kawano, Y Wada, T Maeda… - Frontiers in Cellular …, 2022 - frontiersin.org
Immune cells play numerous roles in the host defense against the invasion of
microorganisms and pathogens, which induces the release of inflammatory mediators (eg …

Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go–related gene) K+ channel subunits

JR Schwarz, S Freitag, Y Pechmann… - Science …, 2024 - science.org
Potassium channels stabilize the resting potential and neuronal excitability. Among them,
erg (ether-à-go-go–related gene) K+ channels represent a subfamily of voltage-gated …

G-csf increases calprotectin expression, liver damage and neuroinflammation in a murine model of alcohol-induced aclf

M Ortega-Ribera, Y Zhuang, V Brezani… - Frontiers in Cell and …, 2024 - frontiersin.org
Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as
a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We …

Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK

SAAG Morsy, MH Fathelbab, NS El-Sayed… - Journal of Neuroimmune …, 2024 - Springer
Neuroinflammation occurs in response to different injurious triggers to limit their hazardous
effects. However, failure to stop this process can end in multiple neurological diseases …

The ameliorative effects of cannabidiol on methotrexate‐induced neuroinflammation and neuronal apoptosis via inhibiting endoplasmic reticulum and mitochondrial …

MD Unlu, H Asci, M Yusuf Tepebasi… - … of Biochemical and …, 2024 - Wiley Online Library
Methotrexate (MTX) is an antineoplastic agent and has neurotoxic effects. It exerts its toxic
effect on the brain by triggering inflammation and apoptosis. Cannabidiol (CBD) is an agent …

[HTML][HTML] De novo movement disorders associated with COVID-19-A systematic review of individual patients

KS Pillai, S Misra, G Siripurapu, A Aliyar… - Annals of Indian …, 2023 - journals.lww.com
Background: COVID-19 infection is associated with neurological manifestations, including
various types of movement disorders (MD). A thorough review of individual patients with …

[HTML][HTML] Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

ST Xie, WC Fan, XS Zhao, XY Ma, ZL Li… - Pharmacological …, 2023 - Elsevier
Specific medications to combat cerebellar ataxias, a group of debilitating movement
disorders characterized by difficulty with walking, balance and coordination, are still lacking …

Recent Advances in Immune-Mediated Cerebellar Ataxias: Pathogenesis, Diagnostic Approaches, Therapies, and Future Challenges

M Manto, H Mitoma - Brain Sciences, 2023 - mdpi.com
The clinical category of immune-mediated cerebellar ataxias (IMCAs) has been established
after 3 decades of clinical and experimental research. The cerebellum is particularly …

Spall: accurate and robust unveiling cellular landscapes from spatially resolved transcriptomics data using a decomposition network

Z Jiang, W Huang, RHW Lam, W Zhang - BMC bioinformatics, 2024 - Springer
Recent developments in spatially resolved transcriptomics (SRT) enable the
characterization of spatial structures for different tissues. Many decomposition methods have …