HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
L Colin, C Van Lint - Retrovirology, 2009 - Springer
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …
infected patients under HAART since interruption of the treatment inevitably leads to a …
[HTML][HTML] HIV-1 Tat: role in bystander toxicity
D Ajasin, EA Eugenin - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its
role as the transactivator of HIV transcription is well established, other roles associated with …
role as the transactivator of HIV transcription is well established, other roles associated with …
HIV-1 proviral transcription and latency in the new era
A Shukla, NGP Ramirez, I D'Orso - Viruses, 2020 - mdpi.com
Three decades of extensive work in the HIV field have revealed key viral and host cell
factors controlling proviral transcription. Various models of transcriptional regulation have …
factors controlling proviral transcription. Various models of transcriptional regulation have …
Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage
Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in
cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent …
cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent …
Transcription: insights from the HIV-1 promoter
E Ne, RJ Palstra, T Mahmoudi - International review of cell and molecular …, 2018 - Elsevier
In this review, we cover transcription regulation of human immunodeficiency virus type 1
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
(HIV-1) gene expression, focusing on the invaluable contributions, made by HIV research …
Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function
Background Central to the fully competent replication cycle of the human immunodeficiency
virus type 1 (HIV-1) is the nuclear export of unspliced and partially spliced RNAs mediated …
virus type 1 (HIV-1) is the nuclear export of unspliced and partially spliced RNAs mediated …
Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes
Long-standing evidence indicates that quiescent human peripheral blood T lymphocytes
(PBLs) do not support efficient HIV infection. In resting PBLs, reverse transcription of viral …
(PBLs) do not support efficient HIV infection. In resting PBLs, reverse transcription of viral …
What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
GR Campbell, EP Loret - Retrovirology, 2009 - Springer
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat
is an important factor in viral pathogenesis. In addition to its function as the key trans …
is an important factor in viral pathogenesis. In addition to its function as the key trans …
Curing HIV: Pharmacologic approaches to target HIV-1 latency
SK Choudhary, DM Margolis - Annual review of pharmacology …, 2011 - annualreviews.org
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can
halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral …
halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral …