Pancreatic cancer is a disease that has a very high fatality rate and one of the highest
mortality ratios among all major cancers, remaining the fourth leading cause of cancer …

The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its
progression have opened a new era in the treatment of this tumor. Vemurafenib was the first …

Parkinson's disease (PD) is a neurodegenerative disorder that alters either motor or non-
motor activities. Dopamine-based medications can help alleviate symptoms at an early …

Protein kinases are a large family of enzymes catalyzing protein phosphorylation. The
human genome contains 518 protein kinase genes, 478 of which belong to the classical …

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and
30% of patients with CRC experience metastasis. Patients with metastatic colorectal cancer …

ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame‐shift
mutation in colorectal cancer (CRC). However, its expression and biological function were …

An emerging body of evidence has recently recognized the coexistence of epithelial-
mesenchymal transition (EMT) and immune response. However, a systems-level view and …

Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be
the second most prevalent cause of death. The traditional target-directed approach, which is …

Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a
range of biological processes implicated in the response to growth factors like latelet …

Melanoma is one of the most severe cancerous diseases. The cells employ multiple
signaling pathways, such as ERK, HGF/c-MET, WNT, and COX-2 to cause the cell …