DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the
signaling cascade that controls cellular proliferation, differentiation, and survival in response …

Abstract Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic
studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor …

The Kirsten rat sarcoma viral oncogene homologue KRAS is among the most commonly
mutated oncogenes in human cancers, thus representing an attractive target for precision …

Centrosome and spindle pole-associated protein (CSPP1) is a centrosome and microtubule-
binding protein that plays a role in cell cycle-dependent cytoskeleton organization and cilia …

Most tumors are easily missed and misdiagnosed due to the lack of specific clinical signs
and symptoms in the early stage. Thus, an accurate, rapid and reliable early tumor detection …

Background Enhancers are essential in defining cell fates through the control of cell-type-
specific gene expression. Enhancer activation is a multi-step process involving chromatin …

Lung cancer is the leading cause of cancer related deaths. Among the two broad types of
lung cancer, non-small cell lung cancer accounts for 85% of the cases. The study of the …

Abstract Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases play critical roles
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …