Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB)
signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell …

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

Ferroptotic cell death is characterized by iron-dependent lipid peroxidation that is initiated by
ferrous iron and H2O2 via Fenton reaction, in which the role of activating transcription factor …

Urolithin A (UA) is a natural compound that is known to improve muscle function. In this work
we sought to evaluate the effect of UA on muscle angiogenesis and identify the underlying …

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting
to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing …

Degenerative musculoskeletal diseases are structural and functional failures of the
musculoskeletal system, including osteoarthritis, osteoporosis, intervertebral disc …

Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

Background: Unfolded protein response (UPR) is a multifaceted signaling cascade that
alleviates protein misfolding. Although well studied in nucleated cells, UPR in absence of …

Despite the impaired intestinal lipid absorption and low level of visceral fat, the Sod1-
deficient mouse is susceptible to developing liver steatosis. To gain insights into the …

Worldwide, hepatocellular carcinoma (HCC) is considered the sixth most prevalent cancer
and ranked third in causes leading to death. Pterostilbene (PTE), a dimethylated analog of …