Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Role of prenatal hypoxia in brain development, cognitive functions, and neurodegeneration

NN Nalivaeva, AJ Turner, IA Zhuravin - Frontiers in neuroscience, 2018 - frontiersin.org
This review focuses on the role of prenatal hypoxia in the development of brain functions in
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …

Selective vulnerability of late oligodendrocyte progenitors to hypoxia–ischemia

SA Back, BH Han, NL Luo, CA Chricton… - Journal of …, 2002 - Soc Neuroscience
In the premature infant, hypoxic-ischemic damage to the cerebral white matter
[periventricular leukomalacia (PVL)] is a common and leading cause of brain injury that often …

Plasticity in the neonatal brain following hypoxic‐ischaemic injury

E Rocha-Ferreira, M Hristova - Neural plasticity, 2016 - Wiley Online Library
Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Dexmedetomidine produces its neuroprotective effect via the α2A-adrenoceptor subtype

D Ma, M Hossain, N Rajakumaraswamy… - European journal of …, 2004 - Elsevier
Which of the three α2-adrenoceptor subtypes of α2A, α2B, or α2C mediates the
neuroprotective effect of dexmedetomidine was examined in cell culture as well as in an in …

Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury

KN Segovia, M McClure, M Moravec… - Annals of Neurology …, 2008 - Wiley Online Library
Objective Abnormal myelination is a major pathological sequela of chronic periventricular
white matter injury in survivors of premature birth. We tested the hypothesis that myelination …

Rodent hypoxia–ischemia models for cerebral palsy research: a systematic review

P Rumajogee, T Bregman, SP Miller, JY Yager… - Frontiers in …, 2016 - frontiersin.org
Cerebral palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5–3/1000
live term births, and up to 22/1000 prematurely born babies. CP results from injury to the …

Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human

A Craig, NL Luo, DJ Beardsley, N Wingate-Pearse… - Experimental …, 2003 - Elsevier
The development of a rodent model in the perinatal rat or mouse that reproduces the
principal features of human perinatal white matter injury (periventricular leukomalacia) has …

Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model

J Cai, Z Kang, WW Liu, X Luo, S Qiang, JH Zhang… - Neuroscience …, 2008 - Elsevier
Hypoxia–ischemia (HI) brain injury is a major cause of neuronal cell death especially
apoptosis in the perinatal period. This study was designated to examine the effect of …

[HTML][HTML] Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic–ischemic brain injury

MM Daadi, AS Davis, A Arac, Z Li, AL Maag… - Stroke, 2010 - journals.lww.com
Background and Purpose—Hypoxic–ischemic (HI) brain injury in newborn infants
represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell …