High blood glucose level (hyperglycemia) is a leading indicator of diabetes mellitus (DM).
Erythrocytes are the most abundant cells in the circulation and the first to perceive changes …

This review summarizes the recent research development on mammalian sialidase
molecular cloning. Sialic acid–containing compounds are involved in several physiological …

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb
complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb …

Alternations of sialic acid (SA) content on cell surface glycan chains have been implicated in
numerous normal and pathological processes including developments, differentiations, and …

Objective Hyperglycaemia has multiple effects on the red blood cell (RBC), including
glycation of haemoglobin, reduced deformability and reduced lifespan. Red cell distribution …

Diabetes mellitus (DM) is a metabolic disorder characterized by varying or persistent
hyperglycemia either due to insufficient production of insulin by pancreas or improper …

Plasma membrane-associated sialidase is a key enzyme for ganglioside hydrolysis, thereby
playing crucial roles in regulation of cell surface functions. Here we demonstrate that mice …

Hemoglobin (Hb) released during hemolysis is a potent oxidant. Extracorpuscular Hb may
enter the vessel wall and mediate low-density lipoprotein oxidation, thereby promoting the …

Diabetes mellitus (DM) is the third most common non-infectious disease leading to early
disability and high mortality. Moreover, the number of patients is growing every year. The …

Erythrocytes are deeply sensitive cells and important health indicators. During inflammatory
response RBC, as a part of haematological system, are exposed to circulating inflammatory …