Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal,
and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common …

Viruses have been recognized as the etiological agents responsible for many pathological
conditions ranging from asymptomatic infections to serious diseases, even leading to death …

Annual and sporadic influenza outbreaks pose a great threat to human health and the
economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen …

Reverse transcriptase (RT) plays an indispensable role in the replication of human
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …

In the search for new anti-influenza virus (IV) compounds, we have identified the 1, 2, 4-
triazolo [1, 5-a] pyrimidine (TZP) as a very suitable scaffold to obtain compounds able to …

Two years after its emergence, SARS-CoV-2 still represents a serious and global threat to
human health. Antiviral drug development usually takes a long time and, to increase the …

Influenza is an acute respiratory infectious disease caused by the influenza virus, affecting
people globally and causing significant social and economic losses. Due to the inevitable …

Influenza viruses (IV) are single-stranded RNA viruses with a negative-sense genome and
have the potential to cause pandemics. While vaccines exist for influenza, their protection is …

The identification of new targets to address unmet medical needs, better in a personalized
way, is an urgent necessity. The introduction of PARP1 inhibitors into therapy, almost ten …

To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of
novel boron-containing N-substituted oseltamivir derivatives were designed and …