The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

NRF2, a transcription factor that has been deemed the master regulator of cellular redox
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

Rationale: NRF2, a redox sensitive transcription factor, is up-regulated in head and neck
squamous cell carcinoma (HNSCC), however, the associated impact and regulatory …

Sesquiterpene lactones constitute a major class of bioactive natural products. One of the
naturally occurring sesquiterpene lactones is costunolide, which has been extensively …

The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …