In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Normal human cells undergo a finite number of cell divisions and ultimately enter a
nondividing state called replicative senescence. It has been proposed that telomere …

Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous …

Scientific discoveries are each individual and occur by their own unique path. However,
there are key ingredients that set the stage for them. Many of these ingredients were …

Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal
human somatic cells but is reactivated during tumor progression. We report the cloning of a …

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome
termini in most eukaryotes. Telomerase RNA components have been identified from many …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence
(for example, TTAGGG in vertebrates 1). In most normal human cells, telomeres shorten with …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …