Skin, our first interface to the external environment, is subjected to oxidative stress caused
by a variety of factors such as solar ultraviolet, infrared and visible light, environmental …

Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left
unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express …

Redox homeostasis is maintained by the antioxidant defense system, which is responsible
for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

Human skin is repeatedly exposed to UVR that influences the function and survival of many
cell types and is regarded as the main causative factor in the induction of skin cancer. It has …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

Photo-induced damage to proteins occurs via multiple pathways. Direct damage induced by
UVB (λ 280–320 nm) and UVA radiation (λ 320–400 nm) is limited to a small number of …

This review article focuses on a critical survey of the main available information on the UVB
and UVA oxidative reactions to cellular DNA as the result of direct interactions of UV …

Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically
linked to skin cancer, a spectrum of diseases of rising incidence in many human …