DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

We have used a realistic model for double-stranded DNA and Monte Carlo simulations to
compute the extension (mean span) of a DNA molecule confined in a nanochannel over the …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Next generation sequencing (NGS) is revolutionizing all fields of biological research but it
fails to extract the full range of information associated with genetic material. Optical mapping …

DNA confinement in nanochannels is emerging as an important tool for genomics and an
excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge …

DNA conformation in slitlike confinement is studied using Monte Carlo simulation and
scaling theory. We focus on analysing the in-plane DNA extension as a function of slit height …

How confinement or a physical constraint modifies polymer chains is not only a classical
problem in polymer physics but also relevant in a variety of contexts such as single-molecule …