Manganese (Mn) is an essential element that is involved in the synthesis and activation of
many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In …

The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

Obesity is a worldwide pandemic in adults as well as children and adds greatly to health
care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular …

Paternal life experiences impact offspring health via germline, and epigenetic inheritance
provides a potential mechanism. However, global reprogramming during offspring …

Uncorrected obesity has been associated with cardiac hypertrophy and contractile
dysfunction. Several mechanisms for this cardiomyopathy have been identified, including …

Adverse early life experiences are major influences on developmental trajectories with
potentially life-long consequences. Prenatal or early postnatal exposure to stress …

The increasing prevalence of metabolic diseases places a substantial burden on human
health throughout the world. It is believed that predisposition to metabolic disease starts …

Noncommunicable diseases, including cardiovascular disease, diabetes, chronic respiratory
disease, and cancer, are the leading cause of death in the world. The cost, both monetary …

Epigenetics is involved in the altered expression of gene networks that underlie insulin
resistance and insufficiency. Major genes controlling β-cell differentiation and function, such …

Human health is facing a host of new threats linked to unbalanced diets, including high-
sugar diet (HSD), which contributes to the development of both metabolic and behavioral …