Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

Polyomaviruses are DNA tumor viruses with small circular genomes encoding only six
proteins including three structural capsid proteins. Despite this simplicity, our understanding …

Infection of the gastrointestinal tract by the human polyomavirus, JCV, which has been
frequently detected in raw urban sewage, can occur via intake of contaminated water and …

A number of recent studies have reported the detection of the ubiquitous human
polyomavirus, JC virus (JCV), in samples derived from several types of neural as well as non …

The type I IFNs (IFN-α and IFN-β), which are crucial in antiviral defense and immune
regulation, signal via the Janus kinase/signal transducer and activator of transcription …

Objective Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating
disease of the white matter affecting immunocompromised patients that results from the …

JC virus (JCV) is a human polyomavirus of the Polyomaviridae family, which also includes
BK virus and simian vacuolating virus 40 (SV40). JC virus was first isolated in 1971 from the …

Polyomaviruses are small, nonenveloped DNA viruses, which are widespread in nature. In
immunocompetent hosts, the viruses remain latent after primary infection. With few …

Cytokines are plurifunctional mediators of cellular communication. The CNS biology of this
family of molecules has been explored by transgenic approaches that targeted the …

Cancer is the second leading cause of mortality worldwide. The study of DNA tumor-
inducing viruses and their oncoproteins as a causative agent in cancer initiation and tumor …