The enteric nervous system is the part of the autonomic nervous system that directly controls
the gastrointestinal tract. Derived from a multipotent, migratory cell population called the …

Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

More than 10 10 cells are generated every day in the human intestine. Wnt proteins are key
regulators of proliferation and are known endogenous mitogens for intestinal progenitor …

In situ hybridization revealed that GDNF mRNA in the mid-and hindgut mesenchyme of
embryonic mice was minimal at E10. 5 but was rapidly elevated at all gut regions after E11 …

Neural crest-derived cells that form the enteric nervous system undergo an extensive
migration from the caudal hindbrain to colonize the entire gastrointestinal tract. Mice in …

Cell migration is fundamental to organogenesis. During development, the enteric neural
crest cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize …

Aims: Enteric nervous system (ENS) progenitor cells have been postulated to be an
appropriate source of cells for the treatment of Hirschsprung's disease. In order for this to be …

A general mathematical model of cell invasion is developed and validated with an
experimental system. The model incorporates two basic cell functions: non-directed …

This review, which is presented in two parts, summarizes and synthesizes current views on
the genetic, molecular, and cell biological underpinnings of the early embryonic phases of …

The development of cell-based therapies for diseased tissues is one of the most promising
research directions in regenerative medicine. Cell-delivery methods are an essential part of …