Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

The mechanisms underlying sterol transport in mammalian cells are poorly understood. In
particular, how cholesterol internalized from HDL is made available to the cell for storage or …

Despite significant improvements during the past 3 decades, cardiovascular disease
remains a leading worldwide health epidemic. The recent identification of a fascinating …

Long noncoding RNAs (lncRNAs) play important roles in various biological processes such
as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA …

Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour
suppressors involved in carcinogenesis. Here we characterized an oncogenic long …

Nuclear receptors regulate gene expression in response to environmental cues, but the
molecular events governing the cell type specificity of nuclear receptors remain poorly …

Atherosclerosis is one of the primary causes of cardiovascular disease and mortality. This
chronic immunometabolic disease evolves during decades in humans and encompasses …

Atherosclerotic cardio-cerebrovascular disease and death remain the leading cause of
morbidity and mortality worldwide. Defective efferocytosis, the clearance of apoptotic cells by …

Hepatocellular carcinoma (HCC) is the most prevalent liver cancer, characterized by a high
rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to …