Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Given the important agricultural and medicinal application of optically pure heterocycles
bearing a trifluoromethyl group at the stereogenic carbon center in the heterocyclic …

A series of novel 2-(5-hydroxy-5-trifluoromethyl-4, 5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)
thiazoles (6) were synthesized by condensing 3-(2-bromoacetyl) coumarins (4) with various …

Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence
and affords the biologically important chiral 3, 5‐diaryl‐5‐(trifluoromethyl)‐2‐isoxazolines 1 …

Searching for new anti-inflammatory agents, we have prepared a series of potential COX-2
inhibitors, 1-(4, 6-dimethylpyrimidin-2-yl)-5-hydroxy-5-trifluoromethyl-Δ 2-pyrazolines (3) and …

A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from
functionalized halogenoximes is reported. One-pot metal-free [3+ 2] cycloaddition of CF3 …

Isoxazoline and isoxazole derivatives are an important class of nitrogen and oxygen
containing heterocycles that are well known to display an array of various biological …

The enantioselective cross-aldol reaction between o-hydroxyacetophenones and
trifluoromethyl ketones catalyzed by chiral thiourea organocatalysts is reported. Gram-scale …

We describe a general method for the synthesis of 5-(trifluoromethyl) isoxazoles by
denitrogenative cyclization of vinyl azides with trifluoroacetic anhydride in the presence of …

Addieren leicht gemacht: Die Aktivierung aromatischer Isoxazole durch eine Nitrogruppe in
4‐Stellung führte zur ersten regio‐und diastereoselektiven Trifluormethylierung von …