Regulation and inhibition of the DNA sensor cGAS
J Hertzog, J Rehwinkel - EMBO reports, 2020 - embopress.org
Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …
LRRC8A: C/E heteromeric channels are ubiquitous transporters of cGAMP
Summary Extracellular 2′ 3′-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported
by diseased cells and imported into host cells to activate the innate immune STING pathway …
by diseased cells and imported into host cells to activate the innate immune STING pathway …
Structure-aided development of small-molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP
Cancer cells initiate an innate immune response by synthesizing and exporting the small-
molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon …
molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon …
Paclitaxel induces micronucleation and activates pro-inflammatory cGAS–STING signaling in triple-negative breast cancer
Y Hu, BK Manasrah, SM McGregor, RF Lera… - Molecular cancer …, 2021 - AACR
Taxanes remain one of the most effective medical treatments for breast cancer. Clinical trials
have coupled taxanes with immune checkpoint inhibitors in patients with triple-negative …
have coupled taxanes with immune checkpoint inhibitors in patients with triple-negative …
Classes of therapeutics to amplify the immune response
Y Hu, ME Burkard - Breast Cancer Research and Treatment, 2022 - Springer
Purpose Conventional chemotherapies are a mainstay for metastatic breast cancers, though
durable response is rare. Immunotherapies promise long-term responses thorough immune …
durable response is rare. Immunotherapies promise long-term responses thorough immune …
Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1
JA Carozza, AF Cordova, Y AlSaif, V Böhnert… - bioRxiv, 2021 - biorxiv.org
The biology of the immune second messenger cGAMP depends on its cellular localization.
cGAMP, which is synthesized in response to cytosolic double-stranded DNA, also exists in …
cGAMP, which is synthesized in response to cytosolic double-stranded DNA, also exists in …