Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects

PJ Slator, M Palombo, KL Miller… - Magnetic resonance …, 2021 - Wiley Online Library
Microstructure imaging seeks to noninvasively measure and map microscopic tissue
features by pairing mathematical modeling with tailored MRI protocols. This article reviews …

TE dependent Diffusion Imaging (TEdDI) distinguishes between compartmental T2 relaxation times

J Veraart, DS Novikov, E Fieremans - NeuroImage, 2018 - Elsevier
Biophysical modeling of macroscopic diffusion-weighted MRI signal in terms of microscopic
cellular parameters holds the promise of quantifying the integrity of white matter …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain

D Benjamini, D Iacono, ME Komlosh, DP Perl… - Brain, 2021 - academic.oup.com
Axonal injury is a major contributor to the clinical symptomatology in patients with traumatic
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …

[HTML][HTML] Probing brain tissue microstructure with MRI: principles, challenges, and the role of multidimensional diffusion-relaxation encoding

B Lampinen, F Szczepankiewicz, J Lätt, L Knutsson… - NeuroImage, 2023 - Elsevier
Diffusion MRI uses the random displacement of water molecules to sensitize the signal to
brain microstructure and to properties such as the density and shape of cells. Microstructure …

Integrated and efficient diffusion-relaxometry using ZEBRA

J Hutter, PJ Slator, D Christiaens, RPAG Teixeira… - Scientific reports, 2018 - nature.com
The emergence of multiparametric diffusion models combining diffusion and relaxometry
measurements provides powerful new ways to explore tissue microstructure, with the …

Mapping astrogliosis in the individual human brain using multidimensional MRI

D Benjamini, DS Priemer, DP Perl, DL Brody… - Brain, 2023 - academic.oup.com
There are currently no non-invasive imaging methods available for astrogliosis assessment
or mapping in the central nervous system despite its essential role in the response to many …

Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact

Q Fan, C Eichner, M Afzali, L Mueller, CMW Tax… - Neuroimage, 2022 - Elsevier
Tremendous efforts have been made in the last decade to advance cutting-edge MRI
technology in pursuit of mapping structural connectivity in the living human brain with …

Combined diffusion‐relaxometry MRI to identify dysfunction in the human placenta

PJ Slator, J Hutter, M Palombo… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo
human placenta, which allows for exploration of coupling between and apparent diffusion …