Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how
researchers approach and answer fundamental biological and pathological questions. In the …

Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes raise the possibility of
generating pluripotent stem cells from a wide range of human diseases. In the cardiology …

Normal developmental progression relies on close interactions between the embryonic and
extraembryonic lineages in the pre-and peri-gastrulation stage conceptus. For example …

A major informatic challenge in single cell RNA-sequencing analysis is the precise
annotation of datasets where cells exhibit complex multilayered identities or transitory states …

ABSTRACT G9a, also known as EHMT2, is essential for embryogenesis and has specific
functions in multiple developmental processes. G9a inactivation affects development of the …

Pioneering work in the chicken established that the initial development of the heart consists
of two stages: the quick assembly of a beating heart, followed by the recruitment of cells from …

The genetic model system Drosophila has contributed fundamentally to our understanding
of mammalian heart specification, development, and congenital heart disease. The relatively …

Publicly available high-throughput gene expression data enable the investigation of
biological processes by the scientific community. Although several bioinformatics tools offer …

Stem cell-based therapy has shown promise for regenerating infarcted heart tissue, yet the
molecular dynamics and cellular fate of transplanted cells within the myocardium remain …

Ischemic heart disease is the most prevalent cause of death globally. Regenerative
cardiology using stem cell-based therapy is a potential approach to replace infarcted …