Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Chemosensing in the gastrointestinal tract is less well understood than many aspects of gut
mechanosensitivity; however, it is important in the overall function of the GI tract and indeed …

BACKGROUND & AIMS:: Long-chain fatty acid receptors G-protein− coupled receptor 40
(GPR40)(FFAR1) and GPR120 have been implicated in the chemosensation of dietary fats. I …

Ingestion of food simultaneously activates gastrointes-tinal motility, gastric and pancreatic
secretion, and release of gastrointestinal hormones that, in turn, modulate motor, secretory …

The purpose of this review is to summarize our current understanding of the physiological
roles of apoA-IV in metabolism, and to underscore the potential for apoA-IV to be a focus for …

Traditionally, nutrients such as fatty acids have been viewed as substrates for the generation
of high-energy molecules and as precursors for the biosynthesis of macromolecules …

While epidemiological studies have revealed a strong positive relationship between the
intake of dietary fat with total energy intake and body weight, laboratory-based studies …

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into
intestinal lymph in response to fat absorption. Many physiological functions have been …

Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose
homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food …

The concept of the gut forming the centre of an integrated gut–brain–energy axis—
modulating appetite, metabolism and digestion—opens up new paradigms for drugs that …