Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

INTRODUCTION Molecularly targeted drugs such as imatinib and crizotinib have
revolutionized the treatment of certain blood and lung cancers because of their remarkable …

Canine primary lung cancer (cPLC) is a rare malignant tumor in dogs, and exhibits poor
prognosis. Effective therapeutic drugs against cPLC have not been established yet. Also …

X-ray imaging technologies have developed rapidly in bioimaging due to their unparalleled
qualities such as nano-spatial resolution, three-dimensional panoramic observation, and …

The rational design of imaging-guided, highly efficient tumor-targeted delivery systems is of
profound importance for improving cancer therapeutic efficacy. Herein, a cRGD peptide …

Integrins play an important role in tumor progression, invasion and metastasis. Therefore we
aimed to evaluate a preclinical imaging approach applying ανβ3 integrin targeted hybrid …

Objectives Nano-drug delivery system is an interesting field in precise cancer treatment, but
few study has reported the microenvironmental changes after such treatment. This study …

When CCD-based free-space fluorescence molecular tomography (FMT) is used for imaging
of fluorescent targets with a large concentration difference, the limited dynamic range of the …

The nonlinear normalized Born ratio (nBorn) method normalizes emission data with
excitation data nonlinearly, which makes the relative distributions of the normalized …

Nuclear imaging plays a critical role in asthma research but is limited in its readings of
biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence …