The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and
germ cells. Differentiation of totipotent cells to somatic lineages occurs at the blastocyst …

Recent advances in molecular technology and in vitro production of bovine embryos have
enabled studies of gene transcription in preimplantation embryos. On the basis of …

We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts.
Two diploid ES cell lines have been cultivated in vitro for extended periods while …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

The derivation of neural progenitor cells from human embryonic stem (ES) cells is of value
both in the study of early human neurogenesis and in the creation of an unlimited source of …

Type 1 diabetes generally results from autoimmune destruction of pancreatic islet β-cells,
with consequent absolute insulin deficiency and complete dependence on exogenous …

The trophectoderm (TE) and inner cell mass (ICM) are committed and marked by reciprocal
expression of Cdx2 and Oct4 in mouse late blastocysts. We find that the TE is not committed …

POU transcription factors are involved in transcriptional regulation during early embryonic
development and cell differentiation. Oct-4, a member of this family, has been shown to be …

Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos
that retain the ability to differentiate into all cell types. This unique feature is the basis of …

The transcription factor Oct‐4 is expressed in totipotent embryonic cells and germ cells. As
totipotent cells differentiate to form somatic and/or extraembryonic tissues, the Oct‐4 gene is …