Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Malaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity
against blood-stage infection reduces parasitemia and disease severity. Duffy-binding …
against blood-stage infection reduces parasitemia and disease severity. Duffy-binding …
Genetic associations with ratios between protein levels detect new pQTLs and reveal protein-protein interactions
K Suhre - Cell genomics, 2024 - cell.com
Protein quantitative trait loci (pQTLs) are an invaluable source of information for drug target
development because they provide genetic evidence to support protein function, suggest …
development because they provide genetic evidence to support protein function, suggest …
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
The Duffy antigen receptor is a seven-transmembrane (7TM) protein expressed primarily at
the surface of red blood cells and displays strikingly promiscuous binding to multiple …
the surface of red blood cells and displays strikingly promiscuous binding to multiple …
Structure‐based design of a Plasmodium vivax Duffy‐binding protein immunogen focuses the antibody response to functional epitopes
TH Dickey, H McAleese, ND Salinas… - Protein …, 2024 - Wiley Online Library
The Duffy‐binding protein (DBP) is a promising antigen for a malaria vaccine that would
protect against clinical symptoms caused by Plasmodium vivax infection. Region II of DBP …
protect against clinical symptoms caused by Plasmodium vivax infection. Region II of DBP …
Structural Space of the Duffy Antigen/Receptor for Chemokines' Intrinsically Disordered Ectodomain 1 Explored by Temperature Replica-Exchange Molecular …
Plasmodium vivax malaria affects 14 million people each year. Its invasion requires
interactions between the parasitic Duffy-binding protein (Pv DBP) and the N-terminal …
interactions between the parasitic Duffy-binding protein (Pv DBP) and the N-terminal …
Structure of the human duffy antigen receptor
The Duffy antigen receptor, also known as FY glycoprotein or CD234, is a seven
transmembrane protein expressed primarily at the surface of red blood cells, which displays …
transmembrane protein expressed primarily at the surface of red blood cells, which displays …
Structure-guided design of a Plasmodium vivax Duffy binding protein-based vaccine immunogen
NM Barber, T Pholcharee, AM Lias, D Quinkert… - bioRxiv, 2024 - biorxiv.org
Plasmodium vivax remains one of the major causative agents of human malaria and a
vaccine is urgently required. It is an obligate intracellular parasites and replication within red …
vaccine is urgently required. It is an obligate intracellular parasites and replication within red …
The biology and pathogenesis of vivax malaria
Plasmodium vivax contributes significantly to global malaria morbidity. Key advances
include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent …
include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent …