An updated evolutionary classification of CRISPR–Cas systems
KS Makarova, YI Wolf, OS Alkhnbashi… - Nature reviews …, 2015 - nature.com
The evolution of CRISPR–cas loci, which encode adaptive immune systems in archaea and
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
bacteria, involves rapid changes, in particular numerous rearrangements of the locus …
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
BACKGROUND Prokaryotes have evolved multiple systems to combat invaders such as
viruses and plasmids. Examples of such defense systems include receptor masking …
viruses and plasmids. Examples of such defense systems include receptor masking …
[HTML][HTML] The CRISPR-Cas immune system: biology, mechanisms and applications
Viruses are a common threat to cellular life, not the least to bacteria and archaea who
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
D Gleditzsch, P Pausch, H Müller-Esparza, A Özcan… - RNA biology, 2019 - Taylor & Francis
Adaptive immunity of prokaryotes is mediated by CRISPR-Cas systems that employ a large
variety of Cas protein effectors to identify and destroy foreign genetic material. The different …
variety of Cas protein effectors to identify and destroy foreign genetic material. The different …
Spatiotemporal control of type III-A CRISPR-Cas immunity: coupling DNA degradation with the target RNA recognition
Streptococcus thermophilus (St) type III-A CRISPR-Cas system restricts MS2 RNA phage
and cuts RNA in vitro. However, the CRISPR array spacers match DNA phages, raising the …
and cuts RNA in vitro. However, the CRISPR array spacers match DNA phages, raising the …
Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system
JR Elmore, NF Sheppard, N Ramia… - Genes & …, 2016 - genesdev.cshlp.org
CRISPR–Cas systems eliminate nucleic acid invaders in bacteria and archaea. The effector
complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR …
complex of the Type III-B Cmr system cleaves invader RNAs recognized by the CRISPR …
CRISPR-based technologies: impact of RNA-targeting systems
MP Terns - Molecular cell, 2018 - cell.com
DNA-targeting CRISPR-Cas systems, such as those employing the RNA-guided Cas9 or
Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and …
Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and …
Degradation of phage transcripts by CRISPR-associated RNases enables type III CRISPR-Cas immunity
Summary Type III-A CRISPR-Cas systems defend prokaryotes against viral infection using
CRISPR RNA (crRNA)-guided nucleases that perform co-transcriptional cleavage of the viral …
CRISPR RNA (crRNA)-guided nucleases that perform co-transcriptional cleavage of the viral …
RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex
MA Estrella, FT Kuo, S Bailey - Genes & development, 2016 - genesdev.cshlp.org
The CRISPR (clustered regularly interspaced short palindromic repeat) system is an RNA-
guided immune system that protects prokaryotes from invading genetic elements. This …
guided immune system that protects prokaryotes from invading genetic elements. This …
CRISPR/Cas9 technology as a potent molecular tool for gene therapy
Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …