The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural
products (such as the anticoagulant warfarin) that display interesting pharmacological …

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating
the sulfation states that determine the function of many physiological molecules. Sulfatase …

The great majority of breast cancers are in their early stage hormone-dependent and it is
well accepted that estradiol (E2) plays an important role in the genesis and evolution of this …

The present invention provides methods for analyzing proteomes, as cells or lysates. The
analysis is based on the use of probes that have specificity to the active form of proteins …

We have recently demonstrated the existence of a neuromodulatory regulation of prolactin
secretion by the opioid system showing a paradoxical opioid-induced prolactin suppression …

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important
role in the formation of both active oestrogens and androgens. Since these steroids …

Synthetic routes to potent steroidal and nonsteroidal sulfamate-based active site-directed
inhibitors of the enzyme steroid sulfatase, a topical target in the treatment of …

Background & aims: The heparin-binding growth factors fibroblast growth factor (FGF) and
hepatocyte growth factor (HGF) are potent mitogens for hepatocellular carcinomas (HCCs) …

Background: There is now abundant evidence that inhibition of steroid sulphatase alone or
in conjunction with inhibition of aromatase may enhance the response of postmenopausal …