Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Background Long-read whole genome sequencing (lrWGS) has the potential to address the
technical limitations of exome sequencing in ways not possible by short-read WGS …

The mTOR signaling network functions as a pivotal regulatory cascade during the
development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of …

Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …

The contractile actomyosin cytoskeleton and its connection to the plasma membrane are
critical for control of cell shape and migration. We identify three STRIPAK complex …

Secretory pathways within dendrites of neurons have been proposed for local transport of
newly synthesized proteins. However, little is known about the dynamics of the local …

The mammalian cerebral neocortex has a well-organized laminar structure, achieved by the
highly coordinated control of neuronal migration. During cortical development, excitatory …

The Golgi apparatus lies at the heart of the secretory pathway where it is required for
secretory trafficking and cargo modification. Disruption of Golgi architecture and function has …

In utero electroporation is a powerful tool to transfect and manipulate neural-precursor cells
of the rodent parietal cortex and their progeny in vivo. Although this technique can …