Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in
which the diagnostic criteria of heart failure are not accompanied by gross disturbances of …

Human aging is associated with skeletal muscle atrophy and functional impairment
(sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major …

Rejuvenation of an old organism was achieved in heterochronic parabiosis experiments,
implicating different soluble factors in this effect. Extracellular vesicles (EVs) are the …

Cardiovascular disease is the main cause of death globally, accounting for over 17 million
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …

Oxidative stress with hydrogen peroxide (H2O2) readily promotes early afterdepolarizations
(EADs) and triggered activity (TA) in isolated rat and rabbit ventricular myocytes. Here we …

Background: Aging per se is a risk factor for reduced cardiac function and heart diseases,
even when adjusted for aging-associated cardiovascular risk factors. Accordingly, aging …

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is frequently
responsible for chronic hyponatremia in the elderly due to age-related disruption of the …

Animal and emerging clinical studies have demonstrated that increased ventricular fibrosis
in a setting of reduced repolarization reserve promotes early afterdepolarizations (EADs) …