Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …

Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …

Background and objectives: Dimensional response is an unmet need in second lines of
advanced soft tissue sarcomas (STS). Indeed, the three approved drugs, pazopanib …

Introduction Local recurrence (LR) is one of the main pitfalls in surgery for extremities soft
tissue sarcoma (eSTS). Achieving clear histopathological margins is the most important …

Background/Aim: The prognosis of metastatic and inoperable sarcomas is extremely poor,
and intensive chemotherapy-based treatment is typically administered to prolong survival …

HMGA1 is a structural epigenetic chromatin factor that has been associated with tumor
progression and drug resistance. Here, we reported the prognostic/predictive value of …

Management of patients with advanced sarcoma has been evolving in recent decades, from
a one-fit-all perspective to a more refined, personalized, and multidisciplinary approach. In …

As a recommended second-line option for advanced soft tissue sarcoma, trabectedin can
provide the necessary balance between long-term tumor control and preserved quality of …

What is the standard indication of adjuvant or neoadjuvant c... : Current Opinion in Oncology
What is the standard indication of adjuvant or neoadjuvant chemotherapy in localized soft-tissue …